Eastern Mediterranean/Aegean Sea cruises visit ports in Turkey, Greece and islands such as Rhodes, Santorini, Mykonos and Crete. Ships traveling this itinerary on seven-day cruises often departing from Piraeus (Athens), Greece, or Istanbul, Turkey, though some longer voyages sail from ports farther west.

Western Mediterranean/Southern Europe cruises sail among the cities and villages of Southern Europe from the Adriatic to the Straits of Gibraltar, including Venice, Naples, Civitavecchia (Rome) and Genoa, Italy; Monte Carlo, Monaco; St.-Tropez, France; Barcelona, Spain; and a host of others, ranging from small villages to major cities.